The best gaming mouse with side buttons can put abilities, macros, shortcuts, and utility commands within easy reach. The right layout depends on how many inputs you need, how much weight you prefer, and whether you want wired or wireless freedom.
Our 2026 roundup covers compact multi-button designs, MMO-focused mice with dense thumb grids, and versatile models that work well for gaming and everyday productivity.
Best 10 Gaming Mouse with Side Buttons Picks for 2026
Best MMO Button Customization
- 12 programmable side buttons for MMO keybinds
- Up to 16,400 DPI with adjustable sensitivity
- Five profiles, RGB lighting, and adjustable weights
Best For: MMO players who need extensive thumb-button customization
Best Lightweight Precision Pick
- HERO 25K sensor with up to 25,600 DPI
- Nine buttons with a customizable DPI-shift control
- Lightweight 89-gram design and dual-mode scroll wheel
Best For: Gamers wanting precise tracking and moderate side-button control
Best Budget MMO Layout
- 12 side buttons and 18 total programmable buttons
- DPI settings from 100 to 12,400 through software
- Switchable polling rates and weight-tuning cartridge
Best For: Players seeking a highly configurable MMO control layout
Best Balanced Side-Button Design
- 11 programmable buttons with a dual-mode scroll wheel
- HERO sensor with up to 25,600 DPI
- Adjustable weights and customizable LIGHTSYNC RGB
Best For: Right-handed gamers wanting versatile controls and precision
Most Versatile
- Swappable 12-, 6-, and 2-button side plates
- Wireless, Bluetooth, and USB-C connectivity
- Up to 280 hours of Bluetooth battery life
Best For: Multi-genre gamers and productivity users
Best Wired Value
- 17 programmable buttons
- Repositionable 12-button side cluster
- 18,000 DPI sensor with 1 DPI adjustment
Best For: Wired MMO and MOBA gaming
Best With Charging Dock
- 12 programmable buttons with six side buttons
- 2.4GHz wireless and USB-C wired modes
- Magnetic charging dock included
Best For: Right-handed MMO players wanting dock charging
MMO Command Center
- 12 programmable side buttons and 18 total buttons
- Up to 12,400 DPI with 1,000 Hz polling
- Five profiles and removable weight tuning
Best For: MMO players who need extensive remappable controls
Maximum Macro Flexibility
- 19 programmable buttons with 12 side buttons
- 100–12,400 DPI and adjustable polling rate
- Five profiles plus weight and RGB customization
Best For: Players who prioritize macros and configuration options
Streamlined MMO Control
- Eight programmable side buttons and 15 total buttons
- Five DPI levels with software customization
- Ergonomic shape and five RGB lighting modes
Best For: MMO players wanting many shortcuts in a simpler layout
Best MMO Button Customization – UtechSmart Venus Pro
The UtechSmart Venus Pro is a gaming mouse with side buttons built for players who want extensive MMO controls, adjustable sensitivity, and profile-based customization. Its 12 thumb buttons, programmable inputs, adjustable weights, and right-handed ergonomic shape make it especially suited to complex keybinds.
Best For: MMO players who need many accessible macros and customizable profiles.
Pros:
- Includes 12 angled side buttons and 19 total buttons for extensive customization.
- Offers adjustable DPI from 200 to 16,400, up to a 1,000Hz polling rate, and a high-precision laser sensor.
- Provides five custom profiles, RGB lighting options, adjustable weights, and a textured right-handed grip.
Cons:
- Its large number of buttons may take time to configure and learn.
- The wired design and Windows-focused compatibility may not suit every setup.
The Venus Pro is a feature-heavy choice when side-button access matters more than simplicity. It is a strong fit for MMO rotations, macros, and games where profile switching and thumb control can streamline play.
Best Lightweight Precision Pick – Logitech G502 X Wired
The Logitech G502 X is a gaming mouse with side buttons for players who want customizable controls without the bulk of a full MMO layout. It combines nine buttons, a removable DPI-shift control, a dual-mode scroll wheel, and the HERO 25K sensor in a lightweight 89-gram design.
Best For: Competitive and general PC gamers who want precise tracking with a moderate number of customizable controls.
Pros:
- HERO 25K tracking provides high precision with up to 25,600 DPI and no smoothing, filtering, or acceleration.
- LIGHTFORCE hybrid optical-mechanical switches are designed for fast actuation and crisp response.
- Includes a reversible, removable DPI-shift button and a hyperfast scroll wheel with tilt controls.
Cons:
- With nine buttons, it offers fewer side controls than dedicated MMO mice.
- It is wired and does not include RGB lighting according to the supplied specifications.
The G502 X is a sensible middle ground for gamers who want side-button utility and high-end sensor performance without committing to a 12-button MMO grid. Its adjustable controls also make it easier to tailor the mouse to different grips.
Best Budget MMO Layout – Redragon M908 Impact
The Redragon M908 Impact is a gaming mouse with side buttons aimed at MMO players who want a dense, programmable control layout. It provides 12 side buttons, 18 total buttons, adjustable DPI settings, switchable polling rates, and a weight-tuning cartridge.
Best For: MMO and strategy players who want many programmable inputs and configurable sensitivity.
Pros:
- Offers 18 buttons, with 18 of 19 listed inputs customizable, including 12 side buttons.
- Supports DPI adjustment from 100 to 12,400 through software and preset mouse-button settings.
- Includes switchable polling rates up to 1,000Hz and a weight-tuning cartridge.
Cons:
- The extensive button layout can require a learning period.
- The supplied details list Windows 2000 as the operating system, so compatibility should be checked for a specific setup.
- Its listed 177-gram weight may feel substantial compared with lightweight gaming mice.
The M908 focuses on control density and customization rather than minimalism. It makes the most sense for players who regularly use numerous macros and prefer the option to tune both sensitivity and mouse weight.
Best Balanced Side-Button Design – Logitech G502 HERO
The Logitech G502 HERO is a gaming mouse with side buttons that balances customizable controls with a familiar right-handed design. Its 11 programmable buttons, HERO sensor, adjustable weights, dual-mode scroll wheel, and LIGHTSYNC RGB make it versatile for both everyday gaming and demanding play.
Best For: Right-handed gamers who want several programmable controls, precise tracking, and adjustable balance.
Pros:
- Provides 11 programmable buttons, including accessible side controls and a dual-mode scroll wheel.
- HERO tracking reaches up to 25,600 DPI without smoothing, filtering, or acceleration.
- Supports five 3.6-gram weights, LIGHTSYNC RGB, and mechanical switch button tensioning.
Cons:
- It is a right-handed wired mouse rather than an ambidextrous model.
- Its 11-button layout offers fewer dedicated MMO side buttons than the 12-button options here.
- RGB customization requires Logitech Gaming Software.
The G502 HERO is a strong all-purpose option for gamers who want more controls than a basic mouse but do not need a full MMO keypad. Its adjustable weight system and precise sensor also make it easy to personalize for different play styles.
Most Versatile – Razer Naga V3 Pro
The Razer Naga V3 Pro is a highly adaptable gaming mouse with side buttons, letting you switch between 12-, 6-, and 2-button side plates for different genres. It also combines wireless, Bluetooth, and USB-C connectivity with extensive software customization.
Best For: Players who move between MMO, MOBA, FPS, and productivity tasks.
Pros:
- Three swappable side-plate layouts support different games and workflows.
- Razer Synapse enables button remapping, macros, and performance adjustments.
- Offers HyperSpeed wireless, Bluetooth, and USB-C wired modes.
- Rated for up to 155 hours on HyperSpeed or 280 hours on Bluetooth.
Cons:
- Full customization is available on Windows, while macOS supports core functions and onboard settings.
- The many controls and 4.16-ounce weight may take time to adapt to.
With its interchangeable layouts and long battery life, the Naga V3 Pro is a strong choice when you want one gaming mouse with side buttons for several genres rather than a mouse dedicated to a single game type.
Best Wired Value – Corsair Scimitar RGB Elite
The Corsair Scimitar RGB Elite is a wired gaming mouse with side buttons built around MMO and MOBA play. Its 12-button side cluster can be repositioned with the Key Slider Control System, while 17 programmable buttons support frequent commands and macros.
Best For: MMO and MOBA players who prefer a dependable wired connection.
Pros:
- Provides 17 programmable buttons, including 12 repositionable side buttons.
- The 18,000 DPI optical sensor adjusts in 1 DPI increments.
- Contoured right-handed shape includes a supporting finger rest.
- Omron switches are rated for 50 million clicks, with a braided cable for durability.
Cons:
- Wired-only connectivity limits cable-free setup flexibility.
- The numerous side buttons are primarily suited to MMO and MOBA command-heavy play.
The Scimitar RGB Elite makes sense if you want lots of accessible controls and adjustable side-button positioning without managing a rechargeable battery or wireless connection.
Best With Charging Dock – ASUS ROG Spatha X
The ASUS ROG Spatha X is a right-handed wireless gaming mouse with side buttons that provides 12 programmable controls, including six side buttons. It supports low-latency 2.4GHz wireless and USB-C wired modes, and includes a magnetic charging dock.
Best For: MMO players who want a large mouse with wireless play and dock-based charging.
Pros:
- Six side buttons contribute to 12 programmable controls.
- Includes a magnetic charging dock and USB-C charging option.
- Offers up to 67 hours of battery life with RGB lighting off.
- Hot-swappable switches and included replacement switches support customization and maintenance.
Cons:
- Its 168-gram design and large shape may not suit users seeking a lightweight mouse.
- Battery life is shorter than the supplied figures for some competing wireless models.
- It is designed for right-handed use.
The Spatha X is a practical pick for MMO-focused setups where a substantial grip, programmable side controls, and a dedicated charging dock matter more than minimizing weight.
MMO Command Center – Redragon M908 Impact
If you need a gaming mouse with side buttons for MMO hotkeys, the Redragon M908 offers an unusually extensive control layout. Its 12 programmable side buttons join 18 total buttons, adjustable DPI, RGB lighting, onboard profiles, and removable weights in a right-handed wired design.
Best For: MMO players who want many remappable controls and adjustable weight balance.
Pros:
- 12 programmable side buttons and 18 total buttons support extensive MMO keybinds.
- Adjustable sensitivity reaches 12,400 DPI, with 1,000 Hz polling and a Pixart PAW3327 optical sensor.
- Five memory profiles, RGB lighting, and eight removable 2.4 g weights add customization.
Cons:
- The 175 g weight and large button layout may feel bulky for some users.
- It is a wired, right-handed mouse rather than a compact or ambidextrous option.
- Programmable features require compatible software; Mac use is listed as normal use only.
The M908 is a strong fit when side-button capacity matters more than simplicity. Its large control array and tuning options are especially useful for MMO rotations and complex shortcuts.
Maximum Macro Flexibility – Redragon M901K
The Redragon M901K is a gaming mouse with side buttons built for players who want deep customization. It combines 12 remappable side buttons with 19 programmable buttons, adjustable DPI and polling rates, five memory profiles, RGB modes, and removable weights.
Best For: MMO and MOBA players who want extensive macros, profiles, and physical balance adjustment.
Pros:
- All 19 buttons can be remapped, including 12 side buttons.
- Adjustable 100–12,400 DPI and 125–1,000 Hz polling rate suit varied play styles.
- Five memory profiles, two working modes, RGB lighting, and eight removable 2.4 g weights provide broad customization.
Cons:
- The many buttons may require an adjustment period and can feel crowded.
- Its corded design limits cable-free flexibility.
- The listed minimum operating systems are Windows 10, macOS 12 Monterey, and Ubuntu 22.04.
Among these options, the M901K stands out for its 19-button layout and detailed configuration range. Choose it when macro access and profile switching are priorities.
Streamlined MMO Control – Redragon M811 Aatrox
The Redragon M811 is a practical gaming mouse with side buttons for MMO shortcuts without the M908 or M901K’s larger button count. It provides eight programmable side buttons, 15 total programmable buttons, five DPI levels, RGB modes, and an ergonomic right-handed shape.
Best For: MMO gamers who want substantial side-button access in a somewhat simpler layout.
Pros:
- Eight programmable side buttons and 15 total buttons support customizable keybinds.
- Five DPI levels are easy to switch, with software customization available between 500 and 12,400 DPI.
- Ergonomic shaping, five RGB backlight modes, and dedicated software add practical flexibility.
Cons:
- It has fewer side buttons and a lower listed maximum sensitivity than the M901K.
- The 200 g weight may not suit users seeking a lightweight mouse.
- It is wired and designed for right-handed use.
The M811 balances MMO functionality with a less demanding control scheme than 12-side-button models. It is a sensible choice if you want programmable side buttons while keeping the overall layout more manageable.
How We Picked the Best Gaming Mouse with Side Buttons
We focused on models that offer more accessible controls than a standard gaming mouse, while comparing button count, layout, sensor resolution, connection options, ergonomics, and customization. The selection includes wired and wireless mice, traditional two-column side-button layouts, and MMO designs with large thumb grids.
Specifications such as DPI are useful for understanding adjustment range, but they do not automatically indicate better tracking. Software support, button placement, shape, and reliable switches often matter more during real use. Weight and hand fit were also considered because a feature-rich mouse can become uncomfortable during long sessions.
Quick Comparison
| Type | Best For | What to Look For |
|---|---|---|
| 2–6 side buttons | FPS, general gaming, productivity | Comfort, low weight, easy thumb access |
| 8–12 side buttons | MMO and MOBA players | Distinct button spacing and software remapping |
| 12+ programmable buttons | Complex rotations and macros | Thumb-grid ergonomics, onboard profiles, stable grip |
| Wireless MMO mouse | Flexible desk setups | Battery life, charging options, connection stability |
Key Buying Factors for a Gaming Mouse with Side Buttons
Button Layout and Accessibility
More buttons are not always better. Choose a layout that lets you identify each control by touch without moving your thumb excessively. A dense grid is powerful for MMO hotbars, while fewer, larger buttons are usually easier for mixed gaming and everyday use.
Shape, Weight, and Hand Size
Most multi-button mice are right-handed and can be heavier than lightweight FPS models. Check the mouse dimensions and grip style before buying. Palm and claw grips generally benefit from a supportive shell, while fingertip users may prefer a smaller, lighter design.
Software and Customization
Look for remapping, macro recording, DPI stages, lighting controls, and profile switching. Onboard memory is especially useful if you move between computers or want settings to remain available without running background software.
Wired or Wireless Connectivity
Wired models avoid battery charging and typically cost less. Wireless versions provide a cleaner setup and more movement freedom, but check battery runtime, charging behavior, and whether they support both low-latency wireless and wired operation.
Sensor and Switch Quality
A high maximum DPI is less important than consistent tracking at your preferred sensitivity. Also consider switch durability, scroll-wheel feel, cable flexibility on wired models, and the warranty.
Who Should Buy Which Gaming Mouse with Side Buttons?
- Choose a lighter, lower-button model if you play shooters, want quick aim adjustments, or also use the mouse for office work.
- Choose an MMO mouse with 8–12 side buttons if you manage numerous abilities, inventory commands, or character shortcuts.
- Choose a model with extensive remapping if you use macros, creative applications, or productivity shortcuts alongside games.
- Choose wireless if cable-free movement and a tidy desk matter more than minimizing cost and maintenance.
- Choose wired if you want dependable plug-and-play use, continuous power, and the best value.
Before ordering, confirm operating-system compatibility, software requirements, hand orientation, and return coverage. A well-positioned six-button mouse can be more practical than a crowded layout that causes accidental presses.